Tobey Is the most durable(pumpkin bomb to the face, was able to overpower goblin and get back up despite having taken alot of hits goblin, taken hits from a big sandman, and has the most combat experience so

Andrew has not so much but a good mouth. (Great spider man but he is the weakest of the three spiderman only having but his advantage being distractive)
But he is also very smart (he knows how to perform his father’s web formula and create electric webbing by himself unlike iron boy jr.)

Tom is the strongest of the three (held a building together) but does not have as much fighting experience as the other two (talent is nothing if not put to use) Durable too(hit by a train moving at high speed and tanked it)

Insomniac Spidey is physically inferior to MCU spidey and Tobey as he has trouble stopping a literal car lol,(in the game you see how he struggles to lift debris too.) God damn he has inconsistent strength ( in a comic tie in he supposedly is on par with superior spider man) very inconsistent so just assume he is as strong as Garfield but weaker than both tobey and tom
he has a ton of gadgets(except they are not as good as tom’s) and combat experience(7 years)
Also he is very good at putting his intellect to use and does more often than the other spider-men

As for speed, (we cant do anything with a game character because its the player who determines the speed so ps4 has to go in the middle for speed.)

So ill sum it up:
Speed: Holland- Maguire -PS4- Garfield
Durability: Maguire- holland- PS4- Garfield
Intellect- PS4 SPIDERMAN- Garfield- Holland- Tobey
Strength- Holland -Tobey – Garfield – PS4
Combat XP- Tobey, PS4, Garfield, Tom.

So I have to choose 2 winners as this question was not specific enough
Intellect is nothing without prep time henceforth i have to do 3 scenarios.

1. Everyone is serious and has No Prep time.
Winner: Maguire
Why? In a direct confrontation all the spideys would not kill each other so nobody will stay down and Tobey is the most durable, hence, he’ll keep coming back and getting back up because of his unbroken willpower to keep going until he fulfills his responsibility. It would be a very close one with PS4 being his hardest to beat as they have a ton of experience.

Everyone has no prep time and is Not serious:
Winner: Holland
so they all randomly meet up and decided to fight, Holland has the best gadgets, tobey doesnt feel a need to fight and keep trying, Garfield is just trying to have fun and PS4 feels no need to waste gadgets. But iron boy junior has unlimited access to gadgets so he’ll just use them. Hence he beats all of them.

3.many prep time:
Winner: PS4
PS4 is great at prep time because you could see him single handledly take down a heavily upgraded sinister six by himself and even made a suit to beat doc ock at the end of the game. Hence, if he felt the need to create better gadgets to beat holland’s, he could because holland relied on iron man for tech, andrew is not any smarter and Tobey is just an expert in school.

Hence, garfield is the only loser here