Majority humans were presumably turned into evil toliets (Evident of one of the earlier Skibidi toliet episodes where every human in a restaurant is turned into a toliet).

The Cameramen, an organization, along with other variants such as speakermen and TVmen fight against the toliets and their overlord to stop their domination of the world. Both sides repeatedly field upgraded weapons and versions each season with a escalation of the scale of the war.

The cameramen use many methods to combat toliets, such as flushing them, using plungers to plunge them, or simply destroy them with explosions or blunt force.

Speakermen utilize their speaker systems to project their extremely loud sounds and music to send toliets flying due to the sound waves.

TVmen can project a light from their screens that causes toliets to either commit flushuicide, fight each other, or simply be destroyed/crash.